The eMICE site is designed to offer electronic Models Information, Communication, and Education primarily on the use of animal models in cancer research. Aspects of the history of animal research, animal husbandry, techniques for breeding and characterizing animal models, and sources of animal models are introduced. Success stories in the form of Research Uses are also described.
As an outreach mechanism for the Mouse Models of Human Cancer Consortium (MMHCC), eMICE aims to connect with a wide range of users, from the general public interested in this topic, to students and scholars interested in animal research, and medical professionals who need to understand more about the cancer research that is underway using animal systems.
There are twenty five MMHCC Principal Investigators whose research groups connect more than fifty institutions in the U.S. and abroad. Each of these twenty five groups consists of a Principal Investigator, co-Principal Investigators , and various collaborators.
The MMHCC Steering Committee sets the scientific direction for the Consortium, develops and tracks cross-Consortium initiatives, collaborates with the NCI to convene meetings and other outreach activities and to develop the informatics infrastructure to support preclinical models science, and provides continuing advice to the NCI on the needs and priorities for mouse models and the necessary infrastructure, resources, and technologies to support their development and deployment to the research community.
The three Standing Committees of the MMHCC develop guidelines for the use of mouse models to test new interventions for cancer, define validation parameters to assess mouse phenotypes as models of human disease, facilitate the exchange of ideas and resources throughout the MMHCC, guide the functioning of NCI’s Mouse Repository, and promote interactions between the MMHCC and the scientific community.
Eight Working Group Committees promote the development of models for disease-site specific cancer research applications. An additional Committee, Public-Private Partnerships, promotes interactions among industry, academia and government organizations.
The scientific staff of NCI is integrally related to the Consortium members through specific scientific areas, funding opportunities and administrative processes.
The NCICB Bioinformatics Group is charged with providing bioinformatics support for the MMHCC. Bioinformatics support includes developing data repositories and access to MMHCC information, providing tools in support of MMHCC data analysis, and integrating MMHCC data with other NCICB projects.