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Mouse - Skin - MC02-0432.pff

MC02-0432.pff image submitted by Robert Cardiff

Image Name: MC02-0432.pff

Image Annotation: Squamous cell carcinoma arising in an abasic endonuclease +/- mouse treated with a two-step chemical carcinogenesis protocol. The diagnosis of carcinoma is based on the presence of microinvasive squamous nests at the deep aspect of the lesion. This tumor exhibits a crater- like growth pattern reminiscent of that seen in keratoacanthoma, however, the diagnosis of human keratoacanthoma is based on the clinical observation that these lesions rapidly regress, a phenomenon that is infrequently observed in mice. The pathology panel therefore discourages the use of keratoacanthoma as a diagnosis and suggests that it can be used as a method of describing a crater-like growth pattern seen in some squamous proliferative lesions. Marcus Bosenberg

Staining Method: Hematoxylin and Eosin Staining Method

Species: Mouse
Strain: unspecified

Organ: Skin


Gene: abasic endocumlease


Image donated by: Robert Cardiff