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Mouse - Skin - skin_011.tif

skin_011.tif submitted by Marcus Bosenberg

Image Name: skin_011.tif

Image Annotation: S100 immunoperoxidase staining of a melanoma from the ear of a Tyr-RasV12G Ink4a-/- mouse. Focal staining for S100 is present in the epithelioid cells of the tumor. TRP1 staining was similar in this case. These findings support the diagnosis of melanoma and are consistent with previous observations that melanomas containing activated Ras alleles frequently downregulate melanocyte differentiation antigens such as TRP1.

Staining Method: Family of calcium binding proteins

Species: Mouse
Strain: FVB mixed

Organ: Skin
Diagnosis: Amelanotic Spindle and Epithelioid Melanoma

Gender: Male

Promoter: Tyrosinase
Gene: RasV12G, Cdkn2a-/-

Publication: 9353252

Image donated by: Marcus Bosenberg