Mouse - Skin - skin_011.tif
Image Name: skin_011.tif
Image Annotation: S100 immunoperoxidase staining of a melanoma from the ear of a Tyr-RasV12G Ink4a-/- mouse. Focal staining for S100 is present in the epithelioid cells of the tumor. TRP1 staining was similar in this case. These findings support the diagnosis of melanoma and are consistent with previous observations that melanomas containing activated Ras alleles frequently downregulate melanocyte differentiation antigens such as TRP1.
Staining Method: Family of calcium binding proteins
Strain: FVB mixed
Diagnosis: Amelanotic Spindle and Epithelioid Melanoma
Gene: RasV12G, Cdkn2a-/-
Image donated by: Marcus Bosenberg