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Mouse - Skin - skin_017.tif

skin_017.tif submitted by Marcus Bosenberg

Image Name: skin_017.tif

Image Annotation: Amelanotic spindle and epithelioid cell tumor from a Tyr-rtTA tetOp-RasV12G Ink4a-/- mouse that had been fed doxycycline. Note the similarity of the morphology and spindle and epithelioid cytology to that skin_9 (JX014). This tumor formed in a mouse that expressed an activated form of Ras in a doxycline-inducible manner, which was administered in the drinking water.

Staining Method: Hematoxylin and Eosin Staining Method

Species: Mouse
Strain: FVB

Organ: Skin
Diagnosis: Amelanotic Spindle and Epithelioid Melanoma


Promoter: Tyrosinase-rtTa
Gene: tetOpRasV12G, Cdkn2a-/-

Publication: 10440378

Image donated by: Marcus Bosenberg