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Mouse - Skin - skin_020.tif

skin_020.tif submitted by Marcus Bosenberg

Image Name: skin_020.tif

Image Annotation: Melanoma arising in a metallothionine-hepatocyte growth factor (MT-HGF) transgenic mouse that has undergone perinatal UV exposure. In contrast to other mouse models of melanoma to date, dramatic intraepidermal spread of melanocytes is present in MT-HGF transgenic mice that have undergone perinatal UV exposure that is better visualized in skin_26 and skin_27. This finding is characteristic of early human melanoma and is called Pagetoid spread. In this case, the tumor has a verrucous low power appearance.

Staining Method: Hematoxylin and Eosin Staining Method

Species: Mouse
Strain: FVB

Organ: Skin
Diagnosis: Mouse Amelanotic Spindle and Epithelioid Melanoma



Publication: 11565020

Image donated by: Marcus Bosenberg