Image Name: skin_034.tif

Image Annotation: Poorly differentiated spindle cell squamous cell carcinoma arising in a HK1-p53R172H mouse treated with a two-stage carcinogenesis protocol. The tumor is composed of spindle cells with admixed cells containing very large pleomorphic nuclei . The diagnosis of squamous cell carcinoma is to some extent based on the presence of a metastasis to a draining lymph node with squamous and spindle cell morphology (see also skin_38-39).

Staining Method: Hematoxylin and Eosin Staining Method

Species: Mouse
Strain:

Organ: Skin
Diagnosis: Spindle-cell Squamous Cell Carcinoma of the Murine Skin

Gender:

Promoter: Human keratin 1
Gene: Mouse mutant p53 (Arg175His)

Publication: 9671312

Image donated by: Marcus Bosenberg