Mouse - Skin - skin_109.tif
Image Name: skin_109.tif
Image Annotation: High power view of the malignant basaloid follicular neoplasm arising as a nodular tumor on the back of a K5-GLI1 transgenic mouse depicted in skin_108. The cylindroma-like architecture has essentially disappeared and cells exhibit nuclear atypia, mitotic activity, and clear cytoplasm. These changes, coupled with the presence of necrosis represent malignant transformation.
Staining Method: Hematoxylin and Eosin Staining Method
Diagnosis: Cylindroma Type of Basaloid Follicular Neoplasm of the Skin
Promoter: Bovine keratin 5
Gene: Human Gli1
Image donated by: Marcus Bosenberg