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Mouse - Skin - skin_135.tif

skin_135.tif submitted by Marcus Bosenberg

Image Name: skin_135.tif

Image Annotation: A nodular tumor arising in a Patched+/- mouse treated with ultraviolet radiation and oral arsenic. This high power view reveals a malignant squamous tumor composed of basaloid cells that abruptly keratinize and form a large keratin-filled cyst. The stromal component adjacent to the epithelium is spindled, cellular, and monotonous (see also skin_133 and skin_137). The morphology of the epithelial component would most commonly be seen in squamous cell carcinoma, but could also be seen in squamoid tumors derived from the follicular epithelium, such as human trichilemmal carcinoma.

Staining Method: Hematoxylin and Eosin Staining Method

Species: Mouse
Strain: C57BL/6 x DBA/2J

Organ: Skin
Diagnosis: Squamous Cell Carcinoma of the Murine Skin


Gene: Patched +/-

Publication: 10545995

Image donated by: Marcus Bosenberg