Mouse - Skin - skin_162.tif
Image Name: skin_162.tif
Image Annotation: Squamous cell carcinoma arising in an abasic endonuclease +/- mouse treated with a two-step chemical carcinogenesis protocol. The diagnosis of carcinoma is based on the presence of microinvasive squamous nests at the deep aspect of the lesion. This tumor exhibits a crateriform growth pattern reminiscent of that seen in keratoacanthoma, however, the diagnosis of human keratoacanthoma is based on the clinical observation that these lesions rapidly regress, a phenomenon that is infrequently observed in mice. The pathology panel therefore discourages the use of keratoacanthoma as a diagnosis and suggests that it can be used as a method of describing a crater-like growth pattern seen in some squamous proliferative lesions.
Staining Method: Hematoxylin and Eosin Staining Method
Diagnosis: Well-differentiated Squamous Cell Carcinoma of the Skin
Gene: Abasic endonuclease +/-
Image donated by: Marcus Bosenberg