Image Name: skin_162.tif

Image Annotation: Squamous cell carcinoma arising in an abasic endonuclease +/- mouse treated with a two-step chemical carcinogenesis protocol. The diagnosis of carcinoma is based on the presence of microinvasive squamous nests at the deep aspect of the lesion. This tumor exhibits a crateriform growth pattern reminiscent of that seen in keratoacanthoma, however, the diagnosis of human keratoacanthoma is based on the clinical observation that these lesions rapidly regress, a phenomenon that is infrequently observed in mice. The pathology panel therefore discourages the use of keratoacanthoma as a diagnosis and suggests that it can be used as a method of describing a crater-like growth pattern seen in some squamous proliferative lesions.

Staining Method: Hematoxylin and Eosin Staining Method

Species: Mouse
Strain:

Organ: Skin
Diagnosis: Well-differentiated Squamous Cell Carcinoma of the Skin

Gender:

Promoter:
Gene: Abasic endonuclease +/-

Publication:

Image donated by: Marcus Bosenberg