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Mouse - Lymphohematopoietic System - 765.pff

765.pff image submitted by Scott Kogan

Image Name: 765.pff

Image Annotation: Model: MRP8 PMLRARa Transgenic Mouse With Myeloid Leukemia. Dx: Myeloid leukemia without maturation with features of human Acute Promyelocytic Leukemia. Leukemic cells develop primarily around the hepatic portal triads but are also dispersed throughout the hepatic parenchyma. Spleen is largely replaced by leukemic cells, scattered megakaryocytes, and islands of dark erythroid cells are present. Small areas of residual lymphoid white pulp are also seen. Sternal bone marrow is filled with leukemic cells, infiltration into surrounding musculature is also seen. 200x

Staining Method: Hematoxylin and Eosin Staining Method

Species: Mouse

Organ: Lymphohematopoietic System
Diagnosis: Myeloid Leukemia without Maturation




Image donated by: Scott Kogan