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National Cancer Institute U.S. National Institutes of Health
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You are here: Home Models by Organ Site Classification of Murine Skin Disorders and Tumors Squamous Cell Carcinoma
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Squamous Cell Carcinoma

Grading of squamous cell carcinomas is an imperfect process. The scheme included below (i.e. well to poorly differentiated) is felt to be usable and relatively repreducible. An alternative grading system is based on the degree of keratinization: grade 1/4 for 75 to 100 % keratinization, grade 2/4 for 50 to 75 %, grade 3/4 for 25 to 50 %, and grade 4/4 for 0 to 25 % keratinization. Another alternative method of grading which the pathology panel finds intriguing but recommends including as data ancillary to the primary diagnosis involves immunoperoxidase staining of tumors with anti-cytokeratin 1, 10, 8, and 18 individually. Grade1/4 tumors are cytokeratin 1 and 10 positive, cytokeratin 8, 18 negative. Grade 2/4 tumors are positive for cytokeratins 1,10, 8, and 18. Grade 3/4 tumors are cytokeratin 1,10 negative and cytokeratin 8,18 positive. Grade 4/4 tumors are negative for cytokeratins 1,10, 8, and 18.