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conditional knockout alleles for both p53 and Rb. Both genes become
full null alleles upon Cre mediated recombination
has been intratracheally infected with AdCre and sacrificed at 25
weeks post infection
contained macroscopic tumor lesions
|Method of Fixation:
Focal neuroendocrine hyperplasia in airway. The basement
membrane is maintained. The cells appear as small cells with little cytoplasm
and hyperchromatic nuclei. The focal undifferentiated lesion seen is in
pulmonary parenchyma and is difficult to determine its origin from airways.
a focus of undifferentiated cells. Many alveolar macrophages
can be seen in adjacent alveoli. An area of poorly differentiated tumor.
Linn, S. C., Linnoila, R. I., Zevenhoven, J., Mooi, W. J., and Berns, A. Induction of
small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional
mouse model. Cancer Cell, 4: 181-189, 2003.