Skip Navigation
National Cancer Institute U.S. National Institutes of Health www.cancer.gov
Personal tools
Document Actions

Slide 065

Slide ID: 065
Collection of murine pulmonary tumors - Slide 065
Click image to enlarge
Submitting Investigator: Tyler Jacks / Erica L. Jackson
Mouse Age: 10 months
Mouse Sex: Male
Mouse Strain: mixed 129/B6
Genotype: conditional K-ras G12D
Genetic Modification Details: floxed transcriptional stop element in the first intron of the K-Ras G12D allele knocked into the K-ras locus
Other Factors: infected with 5*10^7 PFU of AdenoCre virus by intranasal instillation 6 weeks prior to necropsy
Gross Morphology: NA
Method of Fixation: Formalin fixation for ~16 hours
Annotations: Papillary adenoma.
There are a few small variably sized well demarcated densely cellular expansile neoplastic nodules, partially compressing the surrounding pulmonary/alveolar parenchyma. The neoplastic cells are arranged in undulating ribbons or tubular arrays supported by a fine fibrovascular stroma and lined by short columnar crowded epithelium. The neoplastic cells have an oval to round and eccentric basal nuclei with condensed chromatin and moderate amounts of pale eosinophilic cytoplasm. Adjacent to the neoplastic areas or in a random location there are bronchioles lined by hyperplastic and papillary epithelium.
References: Jackson, E. L., Willis, N., Mercer, K., Bronson, R. T., Crowley, D., Montoya, R., Jacks, T., and Tuveson, D. A. (2001). Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243-3248.