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Slide 017

Slide ID: 017
Collection of murine pulmonary tumors - Slide 017
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Submitting Investigator: Alvin M. Malkinson
Mouse Age: 14 months
Mouse Sex: female
Mouse Strain: C57B6
Genotype: wild type
Genetic Modification Details: none
Other Factors: vinyl carbamate
Gross Morphology: none
Method of Fixation: 10 % formalin

Acinar adenocarcinoma.

In one section there is a large mass, replacing most of the lung lobule, composed of undulating tubular irregular arrays lined by cuboidal regularly spaced cells. The lumens of these tubular arrays are distended and contain necrotic cell debris mixed with mucin and eosinophilic acellular material. The neoplastic cells have moderate amounts of cytoplasm with occasional bright eosinophilic granules or variably sized pale basophilic vacuoles (mucin). The nuclei are round to oval and basal with occasional prominent nucleoli and moderate degree of anisokaryosis.
In a small area peripheral to the neoplasm, there are variable numbers of acidophilic and foamy macrophages.