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Slide 071

Slide ID: 071
Collection of murine pulmonary tumors - Slide 071
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Submitting Investigator: Sabine Rehm
Mouse Age: NA
Mouse Sex: NA
Mouse Strain: B6C3F1
Genotype: NA
Genetic Modification Details: none
Other Factors: 3-methylcholanthrene (MCA); induced intratracheally
Gross Morphology: none
Method of Fixation: Formalin
Annotations: Adenosquamous carcinoma.
There are multiple ill defined areas of neoplastic cells and in some areas there is a continuum from tubular papillary undulating arrays lined by single cuboidal epithelium to solid nests of stratified epithelium to lobules with layered keratinized formation some of which have variable amounts of keratin debris. The neoplastic cells are round to cuboidal with moderate amount of eosinophilic cytoplasm with indistinct borders. The nucleus is oval with stippled to vesicular chromatin and prominent small nuclei. Mitotic figures can be seen scattered through out the neoplasia. In some adjacent areas of normal parenchyma there are moderate numbers of foamy macrophages.
References:
Rehm, S., and Kelloff, G. J. (1991). Histologic characterization of mouse bronchiolar cell hyperplasia, metaplasia, and neoplasia induced intratracheally by 3-methylcholanthrene. Exp. Lung. Res. 17, 229-244.