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Neuroendocrine carcinoma

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This is a group consisting of tumors, in which neuroendocrine differentiation has been confirmed by immunohistochemical detection of such proteins as synaptophysin, CGRP and chromogranin. These tumors have only recently been described in mice. Their morphology varies from acinar pattern formation (LW004) to more palisading structures (LW011) to poorly differentiated neoplasms consisting of small hyperchromatic cells with minimal cytoplasm (LW009). Their relevance to human small cell carcinomas and other neuroendocrine carcinomas remains to be determined.

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