conditional knockout alleles for both p53 and Rb. Both genes become
full null alleles upon Cre mediated recombination
has been intratracheally infected with AdCre and sacrificed at 28
weeks post infection
did contain macroscopic tumor lesions
Method of Fixation:
Large tumor mass with necrosis substitutes most of the lung parenchyma.
The neoplastic cells are small to medium size, with scant cytoplasm, and
granular nuclear chromatin. Cells are densely packed and arranged in nesting
pattern. Mitoses are frequent. Metastasis in the regional
Meuwissen, R., Linn, S. C., Linnoila, R. I., Zevenhoven, J.,
Mooi, W. J., and Berns, A. Induction of small cell lung cancer by somatic inactivation of both
Trp53 and Rb1 in a conditional mouse model. Cancer Cell, 4: 181-189, 2003.