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Slide 070

Slide ID: 070
Collection of murine pulmonary tumors - Slide 070
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Submitting Investigator: Sabine Rehm
Mouse Age: NA
Mouse Sex: NA
Mouse Strain: Swiss mice
Genotype: NA
Genetic Modification Details: none
Other Factors: N-nitroso-tris-chloroethylurea, induced cutaneously (skin painting)
Gross Morphology: none
Method of Fixation: Formalin
Annotations: Squamous cell carcinoma.
There are multiple ill-defined areas of neoplastic cells that blend into the adjacent parenchyma and efface the normal pulmonary architecture. The neoplastic cell population ranges from solid closely arranged nests lined by single cuboidal epithelium to large lobules lined by stratified keratinized epithelium with variably sized dilated lumens containing layered parakeratotic epitheliumor aggregates of sloughed neoplastic epithelium. The neoplastic cells are medium to large size with moderate amounts of eosinophilic cytoplasm with indistinct borders, oval to round shape nuclei with stippled chromatin and prominent nuclear membrane and nucleoli. Occasional individual cell keratinization can be seen. A moderate degree of anisokaryosis and megalocytosis are present. The adjacent parenchyma has moderate number of foamy macrophages.
References: Rehm, S., Lijinsky, W., Singh, G., and Katyal, S. L. (1991b). Mouse bronchiolar cell carcinogenesis. Histologic characterization and expression of Clara cell antigen in lesions induced by N-nitrosobis-(2-chloroethyl) ureas. Am. J. Pathol. 139, 413-422.