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J. DeMayo / Bihong Zhao
FGF3 upon RU486 administration
Mouse was treated with RU486 at 500 ug/kg for 1 week.
look pale and enlarged diffusely.
|Method of Fixation:
Entire slide shows diffuse lesions throughout lung around airways, perivascular
and in alveoli. Perivascular, subpleural, peribronchiolar and alveolar
distribution of lesions. The bronchiolar epithelium
is atypical, hyperchromatic and hyperplastic. Most
alveoli are lined by hypertrophic and hyperplastic cells, and cells in
alveolar spaces. Lesions occur perivascular as well. Bronchiolar cells
are multilayered, hyperchromatic and have lost their usual eosinophilic
appearance of normal Clara cells. Lining many alveoli are
a uniform population cuboidal cells sometimes forming glandular structures.
Similar cells are free in the alveolar spaces. There is severe perivascular
alveolar epithelial hyperplasia, with proliferative cells forming glandular
structures in some areas. A few perivascular foci of lymphocytes
can also be observed.
Zhao, B., Chua, S. S., Burcin, M.
M., Reynolds, S. D., Stripp, B. R., Edwards, R. A., Finegold, M.
J., Tsai, S. Y., and DeMayo, F. J. (2001). Phenotypic consequences
of lung-specific inducible expression of FGF-3. Proc. Natl. Acad.
Sci. USA 98, 5898-5903.