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Proliferative Lesions of the Lung

This WEB site contains a digital atlas of virtual histological slides with representative mouse and human pulmonary proliferative lesions. It complements the paper "Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancers Consortium" by Alexander Yu. Nikitin, Ana Alcaraz, Miriam R. Anver, Roderick T. Bronson, Robert D. Cardiff, Darlene Dixon, Armando E. Fraire, Edward W. Gabrielson, William T. Gunning, Diana C. Haines, Matthew H. Kaufman, R. Ilona Linnoila, Robert R. Maronpot, Alan S. Rabson, Robert L. Reddick, Sabine Rehm, Nora Rozengurt, Hildegard M. Schuller, Elena N. Shmidt, William D. Travis, Jerrold M. Ward and Tyler Jacks published in Cancer Research 64: 2307-2316, 2004

Please note that slides frequently have more than one lesion. For didactic purposes, the annotations do not always describe all lesions. All images have been scanned with the ScanScope (Aperio Technologies) equipped with objective 20X. The resulting magnification is about 320 folds. Excessive zooming (in most cases over 3 "zoom in" clicks) will result in magnification exceeding that of the original scan and image will appear out of focus.

Acknowledgments
We thank Drs. Cheryl Marks and Betty Tarnowski (Division of Cancer Biology, NCI, NIH) for their continuous support and encouragement during the duration of this project; Susan Seweryniak (Division of Cancer Biology, NCI, NIH) for her help with organizing the Boston meeting; Drs. Anton Berns and Ralf Meuwissen (Netherlands Cancer Institute, Amsterdam, the Netherlands); Peter Demant (Roswell Park Cancer Institute, Buffalo, NY); Franco J. DeMayo (Baylor University, School of Medicine, Houston, TX); Tommaso A. Dragani (Instituto Nazionale Tumori, Milan, Italy); Erica L. Jackson (Massachusetts Institute of Technology, Cambridge, MA); Sonia B. Jakowlew (NCI, Rockville, MD); Alvin M. Malkinson (University of Colorado, Denver, CO); David A. Tuveson (Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA); Jeffrey A. Whitsett (Children´┐Żs Hospital Medical Center, Cincinnati, OH); Harold E. Varmus (Memorial Sloan Kettering Cancer Institute, New York, NY); Hanspeter Witschi (University of California, Davis, CA); Ming You (Washington University School of Medicine, St. Louis, MO) for kind contribution of histological specimens for evaluation; Keith Rogers and Barbara Kasprzak (Pathology/Histotechnology Laboratory, Science Applications International Corporation, NCI, Frederick, MD) for excellent preparation of histological slides and immunohistochemistry; Andrea Flesken-Nikitin, Indira Gopal, and Sergei Kupriyenko (Nikitin Lab) for help with organizing histological materials and preparing ScanScope virtual slides; Alexander Urban (Nikitin Lab) for computer programming of the digital atlas; Clint Malone (Science Applications International Corporation, NCI Center for Bioinformatics) and Kevin Rosso (Science Applications International Corporation, NCI Center for Bioinformatics) for setting up and maintaining the digital atlas as the WEB site; and Bob Costello (Micro Video Instruments/Nikon USA) for providing SPOT-RT camera and Nikon microscopes.

This work was supported by the Mouse Models of Human Cancers Consortium (MMHCC) Pathology Standing Committee funding (CA84241 and CA84242 to A. Yu. Nikitin) and with Federal funds from the National Cancer Institute, NIH, under contract N01-C0-124000. A. Yu. Nikitin is a recipient of the NCRR, NIH Midcareer Award in Mouse Pathobiology (RR017595).