WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues
The list below present a summary of the WHO classification (Jaffe et al., 2001). The morphology
code of the International Classification of Diseases (ICD-O) is presented. Behavior is coded /3
for malignant tumors and /1 for lesions of low or uncertain malignant potential.
- CHRONIC MYELOPROLIFERATIVE DISEASES
Chronic myelogenous leukemia - ICD-O 9875/3
Chronic neutrophilic leukemia - ICD-O 9963/3
Chronic eosinophilic leukemia / hypereosinophilic syndrome - ICD-O 9964/3
Polycythemia vera - ICD-O 9950/3
Chronic idiopathic myelofibrosis - ICD-O 9961/3
Essential thrombocytemia - ICD-O 9962/3
Chronic Myeloproliferative disease, unclassifiable - ICD-O 9975/3
- MYELODYSPLASTIC / MYELOPROLIFERATIVE DISEASES
Chronic myelomonocytic leukemia - ICD-O 9980/3
Atypical chronic myelogenous leukemia - ICD-O 9876/3
Juvenile myelomonocytic leukemia - ICD-O 9946/3
Myelodysplastic / myeloproliferative diseases, unclassifiable - ICD-O 9975/3
- MYELODYSPLASTIC SYNDROMES
Refractory anemia - ICD-O 9980/3
Refractory anemia with ringed sideroblasts - ICD-O 9982/3
Refractory cytopenia with multilineage dysplasia - ICD-O 9985/3
Refractory anemia with excess blasts - ICD-O 9983/3
Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality - ICD-O 9986/3
Myelodysplastic syndrome, unclassifiable 9989/3
- ACUTE MYELOID LEUKEMIAS
Acute myeloid leukemias with recurrent cytogenetic abnormalities
AML with t(8;21)(q22;q22), AML1/ETO - ICD-O 9896/3
AML with inv(16)(p13q22) or t(16;16)(p13;q22), CBFb/MYH11 - ICD-O 9871/3
Acute promyelocytic leukemia (AML with t(15;17)(q22;q12), PML-RARa and variants) - ICD-O 9866/3
AML with 11q23 (MLL) abnormalities - ICD-O 9897/3
Acute myeloid leukemia multilineage dysplasia- ICD-O 9895/3
Acute myeloid leukemia and myelodysplastic syndrome, therapy related - ICD-O 9920/3
Acute myeloid leukemia not otherwise categorised
Acute myeloid leukemia, minimally differentiated - ICD-O 9872/3
Acute myeloid leukemia, without maturation - ICD-O 9873/3
Acute myeloid leukemia, with maturation - ICD-O 9874/3
Acute myelomonocytic leukemia - ICD-O 9867/3
Acute monoblastic and monocytic leukemia - ICD-O 9891/3
Acute erythroid leukemia - ICD-O 9840/3
Acute megakaryoblastic leukemia - ICD-O 9910/3
Acute basophilic leukemia - ICD-O 9870/3
Acute panmyelosis with myelofibrosis - ICD-O 9931/3
Myeloid sarcoma - ICD-O 9930/3
Acute leukemia of ambiguous lineage - ICD-O 9805/3
- B-CELL NEOPLASMS
Precursor B-cell neoplasm
Precursor B lymphoblastic leukemia / - ICD-O 9835/3
lymphoma - ICD-O 9728/3
Mature B-cell neoplasm
Chronic lymphocytic leukemia/ - ICD-O 9823/3
small lymphocytic lymphoma - ICD-O 9670/3
B-cell prolymphocytic leukemia - ICD-O 9833/3
Lymphoplasmacytic lymphoma - ICD-O 9671/3
Splenic marginal zone lymphoma - ICD-O 9689/3
Hairy cell leukemia - ICD-O 9940/3
Plasma cell myeloma - ICD-O 9732/3
Solitary plasmacytoma of bone - ICD-O 9731/3
Extraosseous plasmacytoma - ICD-O 9734/3
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma) - ICD-O 9699/3
Nodal marginal zone B-cell lymphoma - ICD-O 9699/3
Follicular lymphoma - ICD-O 9690/3
Mantle cell lymphoma - ICD-O 9673/3
Diffuse large B-cell lymphoma - ICD-O 9680/3
Mediastinal (thymic) large cell lymphoma - ICD-O 9679/3
Intravascular large B-cell lymphoma - ICD-O 9680/3
Primary effusion lymphoma - ICD-O 9678/3
Burkitt lymphoma / - ICD-O 9687/3
leukemia - ICD-O 9826/3
B-cell proliferations of uncertain malignant potential
Lymphomatoid granulomatosis - ICD-O 9766/1
Post-transplant lymphoproliferative disorder, pleomorphic - ICD-O 9970/1
- T-CELL AND NK-CELL NEOPLASMS
Precursor T-cell neoplasms
Precursor T lymphoblastic leukemia / - ICD-O 9837/3
lymphoma - ICD-O 9729/3
Blastic NK cell lymphoma - ICD-O 9727/3
Mature T-cell and NK-cell neoplasms
T-cell prolymphocytic leukemia - ICD-O 9834/3
T-cell large granular lymphocytic leukemia - ICD-O 9831/3
Aggressive NK cell leukemia - ICD-O 9948/3
Adult T-cell leukemia/lymphoma - ICD-O 9827/3
Extranodal NK/T cell lymphoma, nasal type - ICD-O 9719/3
Enteropathy type T-cell lymphoma - ICD-0 9717/3
Hepatosplenic T-cell lymphoma - ICD-O 9716/3
Subcutaneous panniculitis-like T-cell lymphoma - ICD-O 9708/3
Mycosis fungoides - ICD-O 9700/3
Sezary Syndrome - ICD-O 9701/3
Primary cutaneous anaplastic large cell lymphoma - ICD-O 9718/3
Peripheral T-cell lymphoma, unspecified -ICD-O 9702/3
Angioimmunoblastic T-cell lymphoma - ICD-O 9705/3
Anaplastic large cell lymphoma - ICD-O 9714/3
T-cell proliferation of uncertain malignant potential
Lymphomatoid papulosis - ICD-O 9718/1
- HODGKIN LYMPHOMA
Nodular lymphocyte predominant Hodgkin lymphoma - ICD-O 9659/3
Classical Hodgkin lymphoma - ICD-O 9650/3
Nodular sclerosis classical Hodgkin lymphoma - ICD-O 9663/3
Lymphocyte-rich classical Hodgkin lymphoma - ICD-O 9651/3
Mixed cellularity classical Hodgkin lymphoma - ICD-O 9652/3
Lymphocyte-depleted classical Hodgkin lymphoma - ICD-O 9653/3
- HISTIOCYTIC AND DENDRITIC-CELL NEOPLASMS
Macrophage / histiocytic neoplasm
Histiocytic sarcoma - ICD-O 9755/3
Dendritic cell neoplasms
Langerhans cell histiocytosis - ICD-O 9751/1
Langerhans cell sarcoma - ICD-O 9756/3
Interdigitating dendritic cell sarcoma/tumor - ICD-O 9757/3 /1
Follicular dendritic cell sarcoma/tumor - ICD-O 9758/3 /1
Dendritic cell sarcoma, not otherwise specified - ICD-O 9757/3
- MASTOCYTOSIS
Cutaneous mastocytosis
Indolent systemic mastocytosis - ICD-O 9741/1
Systemic mastocytosis with associated clonal, hematological non-mast cell lineage disease - ICD-O 9741/3
Aggressive systemic mastocytosis - ICD-O 9741/3
Mast cell leukemia - ICD-O 9742/3
Mast cell sarcoma - ICD-O 9740/3
Extracutaneous mastocytoma - ICD-O 9740/1
Selected References
Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (Eds.) (2001): World Health Organization
Classification of Tumours. Pathology and Genetics of Tumours of Hematopoietic and Lymphoid
Tissues. IARC Press: Lyon.
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