Ovarian Cancer Models
Darcie Hazelton Bailey1,
Denise C. Connolly2,
Barbara Vanderhyden3,
Ken Garson3,
Thomas C. Hamilton2
1Schering-Plough, Kenilworth, NJ
2Fox Chase Cancer Center, Philadelphia, PA
3Ottawa Regional Cancer Center, Ottawa, Canada
Welcome to the MMHCC Ovarian Cancer Site. On this web site, you will find a brief introduction to ovarian cancer, including
Normal Ovarian Development and Biology, Human Ovarian Cancer, and Animal Models of the disease. The introductory section is followed by several sections
with more detailed information and discussion of specific topics listed below:
Introduction
Prevalence
Cancer is the second leading cause of death in the United States, and was responsible
for 23% of deaths in the year 1999.1 Ovarian cancer presents a significant womens'
healthcare concern, responsible for increased morbidity and mortality in women.
Ovarian cancer will be responsible for 4% of the 647,400 new cancer cases
and 5% of the 267,300 cancer deaths occurring in women in the United States in the
year 2002.1
Unfortunately, both the incidence and mortality of ovarian cancer has remained
relatively constant over the past 3 decades.1 This is due in large part to the fact
that the majority of women who are diagnosed, are at a relatively advanced stage of
the disease. Often, the most common symptoms are nonspecific gastrointestinal
distress, bloating, and pressure; symptoms that are often attributed to inconsequential causes.
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