Name of Model

Background Strain

Predominant Location

Predominant Neoplasm

Average Number of Tumors/ Mouse

Age when

Analyzed

Other lesions

Metastasis

Reference

WNT Pathway

Apc^Min/+

C57BL/6

Small Intestine

Adenoma

30

4 months

carcinoma

no

61

Apc^1638N/+

C57BL/6

Small Intestine

Adenoma/Carcinoma

4

12 months

desmoid tumors

Yes (1 reported)

78, 64

Apc^D716/+

C57BL/6

Small Intestine

Adenoma

300

4 months

no

63

Apc^1309/+

NR

Small Intestine

Adenoma

34

3 months

no

98

DN131 b-catenin

C57BL/6 x DBA

Small Intestine

Adenoma

1

1 month

polycystic renal disease

no

66

Activated b-catenin

C57BL/6 x NR

Small Intestine

Adenoma

3000

1 month

no

68

Mismatch repair genes

Msh3^-/-

C57BL/6 x 129/Sv x SJL/J

Small Intestine

Adenoma/Carcinoma

<1

24 months

lymphomas, skin tumors

no

72

Msh3^-/- Apc^1638/+

C57Bl/6

Small/large intestine

Adenoma/Carcinoma

5

9 months

skin tumor

no

80

Msh6^-/-

C57BL/6 x 129/SvJ x SJL/J

Small Intestine

Adenoma/Carcinoma

<1

11 months

lymphomas, skin tumors

no

73

Msh6^-/- Apc^1638/+

C57Bl/6

Small/Large Intestine

Adenoma/Carcinoma

26

5 months

skin tumor

no

80

Msh3^-/- Msh6^-/-

129/Ola x FVB/N

Small Intestine

Adenoma/Carcinoma

1

6 months

skin tumor

no

72

Msh3^-/-Msh6^-/-Apc^1638/+

C57Bl/6

Small/Large Intestine

Adenoma/Carcinoma

40

<3 months

no

80

Mlh1^-/-

C57BL/6 x 129/Ola

Small Intestine

Adenoma/Carcinoma

2

6 months

lymphomas, skin tumors

no

88

Mlh1^+/- Apc^1638/+

C57Bl/6

Small Intestine

Adenoma/Carcinoma

2

6 months

skin tumor

no

88

Mlh1^-/- Apc^1638/+

C57BL/6 x 129/Ola

Small Intestine

Adenoma/Carcinoma

45

3 months

no

88

Mlh1^-/- Apc^Min/+

C57BL/6

Small Intestine

Adenoma

139

2 months

no

89

Msh2^-/-

C57BL/6 x 129/Ola

Small Intestine

Adenoma/Carcinoma

<1

6 months

lymphoma

no

71

TGFb models

Rag2^-/- Tgfb1^-/-

129S6 x CF1

Cecum/Colon

Mucinous Carcinoma

2

2-6 months

no

77

Rag2^-/- Tgfb1^+/-

129S6 x CF1

Cecum/Colon

Adenoma

2

2-6 months

no

77

Smad4^+/-

C57BL/6

Stomach/

Duodenum

Hamartomatous Polyp

2

24 months

No

84

Smad4^+/- Apc^D716/+

C57BL/6

Small Intestine

Carcinoma

300

4 months

signet ring cell carcinoma

84

Smad3^-/-

129/Sv

Colon

Mucinous Carcinoma

NR

6 months

rectal prolapse

yes

83

Smad3^-/-

129 x C57BL/6

Cecum/Colon

Mucinous Carcinoma

NR

NR

rectal prolapse

NR

83

Immunodeficient

Il-10^-/-

C57BL/6 x 129

Colon/Rectum

Colitis/Carcinoma

NR

2-6 months

no

97

Il-2 b2-microglobulin^-/-

C57BL6 x 129

Rectum/Colon

Carcinoma

NR

6-12 months

no

98

Tcrα^-/-

C57BL/6

Rectum/Colon

Colitis

NR

3-12 months

90

Ga_i2^-/-

129Sv x C57BL/6J

Colon

Colitis/Carcinoma

1

3-9 months

altered thymocyte maturation

no

93

Carcinogen Treated

AOM

A/J

Colon

Adenoma/Carcinoma

36

6 months

NR

81

AOM

SWR/J

Colon

Adenoma/Carcinoma

16

6 months

NR

81

AOM

AKR/J

Colon

Adenoma/Carcinoma

<1

6 months

NR

81

MNU

NR

Small Intestine

Adenoma/Carcinoma

1.5

3-12 months

NR

76

MNG

C3H

Colon/ Small Intestine

Adenoma/Carcinoma

<1

11-20 months

Stomach SCC

NR

104

Other Models

Cdx2^+/-

129/Sv x C57BL/6

Colon

gastric & intestinal heterotopia

10

3 months

no

109

Muc2^-/-

C57BL/6 x 129/SvOla

Small & Large Intestine

Adenoma/Carcinoma

1

6-12 months

no

111

PI(3)Kinaseg^-/-

C57BL/6

Rectum/Colon

Carcinoma

1+

3-6 months

peritoneal

82

N-Cadherin^-/-

C57BL/6 x 129/Sv

Small Intestine

Colitis/Adenoma

NR

2-19 months

no

110