Normal Mouse Hematopoiesis and Classification of Hematopoietic and Lymphoid Neoplasms in Mice

A broad spectrum of lymphoid and non-lymphoid (myeloid) hematopoietic neoplasms have been observed in mice. Under the auspices of the MMHCC, the Bethesda Proposals for the Classification of Lymphoid and Non-lymphoid Neoplasms in Mice have been developed. These proposals were published in BLOOD in the summer of 2002. Links to these articles and their on-line supplementary material:

1. Bethesda proposals for classification of nonlymphoid neoplasms in mice.
   Kogan SC et al. Blood. 2002 July
2. Bethesda proposals for classification of nonlymphoid neoplasms in mice.
   Supplemental Materials
3. Bethesda proposals for classification of lymphoid hematopoietic neoplasms in mice.
   Morse HC 3rd et al. Blood. 2002 July
4. Bethesda proposals for classification of lymphoid hematopoietic neoplasms in mice.
   Supplemental Materials

The Supplemental Materials available through the links above include:
Non-Lymphoid
Glossary of terminology
Overview and representative examples
Practical guide to characterization and classification
Questions and answers about the Bethesda proposals for classification
Bibliography

Lymphoid
Recommended approaches to diagnosing lymphoid neoplasms of mice
Occurrence of lymphoid neoplasms in mice
Genetic determinants of lymphoid neoplasms

Additional materials include:
Synoptic Reports (Outline of information useful to collect when analyzing mice with lymphoid and hematopoietic neoplasms):

• Murine Pathology Case Summary Hematopoietic Neoplasms, Lymphoid
• Murine Pathology Case Summary Hematopoietic Neoplasms, Nonlymphoid

Normal Mouse Hematopoiesis and Classification of Hematopoietic and Lymphoid Neoplasms in Mice

1. Non-lymphoid Hematopoietic (Myeloid) Neoplasms
   1. Non-lymphoid Leukemias
      1. Myeloid leukemias IMAGES
         1. Myeloid leukemia without maturation
         2. Myeloid leukemia with maturation
         3. MPD-like myeloid leukemia IMAGES
         4. Myelomonocytic leukemia
         5. Monocytic leukemia
      2. Erythroid leukemia IMAGES
      3. Megakaryocytic leukemia IMAGES
      4. Biphenotypic leukemia
   2. Non-lymphoid Hematopoietic Sarcomas
      1. Granulocytic sarcoma
      2. Histiocytic sarcoma IMAGES
      3. Mast cell sarcoma IMAGES
   3. Myeloid Dysplasias
      1. Myelodysplastic syndrome
      2. Cytopenia with increased blasts
   4. Myeloid Proliferations (non-reactive)
      1. Myeloproliferation (genetic)
      2. Myeloproliferative disease IMAGES
2. Lymphoid Neoplasms
   1. B-cell Neoplasms
      1. Precursor B-cell Neoplasms
         1. Precursor B-cell lymphoblastic lymphoma/leukemia IMAGES
      2. Mature B-cell Neoplasms
         1. Small B-cell lymphoma IMAGES
         2. Splenic marginal zone lymphoma IMAGES
         3. Follicular B-cell lymphoma IMAGES
         4. Diffuse large B-cell lymphoma
            1. Centroblastic IMAGES
            2. Immunoblastic
            3. Histiocyte-associated
         5. Primary Mediastinal (thymic) diffuse large B-cell lymphoma
         6. Classic Burkitt lymphoma
         7. Burkitt-like lymphoma
      3. Plasma Cell Neoplasms
         1. Plasmacytoma IMAGES
         2. Extraosseous plasmacytoma
         3. Anaplastic plasmacytoma
      4. B-Natural Killer Cell Lymphoma
   2. T-cell Neoplasms
      1. Precursor T-cell Neoplasms
         1. Precursor T-cell lymphoblastic lymphoma/leukemia IMAGES
      2. Mature T-cell Neoplasms
         1. Small T-cell lymphoma
      3. T-cell Neoplasms, Character Undetermined
         1. Large cell anaplastic lymphoma
      4. T-Natural Killer Cell Lymphoma
3. Normal Mouse Hematopoiesis and Organogenesis IMAGES

The MMHCC hematopathology sub-committee is continuing its work and invites your participation:
1. A project to further characterize and classify lesions including detailed immunophenotypic analysis is on-going. If you wish to participate please click here.
2. The committee is developing a comprehensive list of available models with links to publications
3. Proposals for classification need continuing refinement.
4. Additional protocols are being assembled

Investigators are invited to contact Scott Kogan (skogan@cc.ucsf.edu) if they wish to contribute to these ongoing projects (see Appendix II).

Selected References

Fredrickson, T.N., et al. (2000) Atlas of mouse hematopathology. Harwood Academic Publishers. Amsterdam, the Netherlands.