- Researchers Test the Specificity of the Fluorescent Probe LUM015 in a Mouse Model of Soft-tissue Sarcoma in a Phase I Co-Clinical Trial.
- A Semi-allogeneic Vaccine Composed of GL261 Cells Has Significantly Prolonged Survival in C57BL/6 Mice Injected Orthotopically With Glioma Cells.
- An Artificial MicroRNA Targeting MAP3K1 Disrupts Breast-cancer Cell Proliferation and Reduces Invasiveness in a Nude Mouse Model.
- Il-18 Enhances the Effectiveness of Immune Checkpoint Blockade in Mice to Reduce Peritoneal Carcinoma Dissemination or Tail-vein Injection of Metastatic Melanoma Cells.
- Researchers Demonstrate That Inhibition of NF-КB Can Significantly Slow Cell Proliferation and Increase Survival time in a Mouse Model of Glioblastoma.
- The Radiopharmaceutical 64Cu-LLP2A (64Cu-CB-TE1A1P-PEG4-LLP2A), a Peptidomimetic of Very-late-antigen-4, Shows High Specificity in Targeting Multiple Myeloma, Which Overexpresses VLA4, in α4-knock-out Mice and Wild-type Syngeneic Tumor-bearing Mice.
- Human Colorectal Risk Factors Relating to Diet and Ultraviolet Light Exposure Induce the Formation of Aberrant Crypt Foci in a Rat Model.
- Researchers Use a Nanoparticle Derived from Tea to Deliver Doxorubicin and Enhance Its Effects in an ABCB1-overexpressing Tumor Xenograft Mouse Model. The technique may provide a means for overcoming multidrug resistance.
- A Patient-derived Xenograft Mouse Model Has Been Developed to Study Parameningeal Embryonal Rhabdomyosarcoma. The model is publicly available from The Jackson Laboratory.
- A Mouse Model of Acute Myeloid Leukemia Expressing the Fusion Gene CALM/AF10 Has Shown That the Target Cell for Transformation Is an Early-Progenitor Cell or a Stem Cell, and Is Not Therefore of B-cell Lineage. The report appears in Nature.
- Researchers Have Developed a Magnetic Nanoparticle Conjoined to a Monoclonal Antibody That Targets the c-erbB-2 Antigen in the Breast Cancer Tissues of a Rat Model.
- Luminescent Nanoparticles Combined With a Custom-built Tumor-specific Imaging Probe Detects Early-stage Colorectal Tumors and Micrometastases With High Specificity in a Mouse Model.
- Investigators Assess the Biodistribution, Tumor Uptake, and Therapeutic Efficacy of Copper-6 4 Dichloride Salt in Xenograft Nude Mouse Models Implanted with Glioblastoma Cell Lines (U-87MG). The results provide evidence that copper-64 dichloride, which has been shown to accumulate preferentially in various tumor types, also preferentially accumulates in glioblastoma tissues, suggesting its potential as a diagnostic probe and therapeutic agent in glioblastoma.
- Researchers Demonstrate That 5-AcTMF, a Derivative of Tangerine Peels, Exhibits Anti-proliferative Effects in Non-small Cell Lung Cancer in a Xenograft Nude Mouse Model.
- Scientists Have Developed a Mouse Model of Pancreatic Ductal Carcinoma with Deletion of Twist or Snail, Transcription Factors that Induce Epithelial-to-mesenchymal Transition (EMT), in Order to Clarify the Roles of the EMT in Promoting Invasiveness and Metastasis and Chemoresistance. They found that epithelial cells that had undergone the transition did not become more invasive or metastatic; however, the cells did become more resistant to chemotherapy. The research is reported in Nature.
- Researchers Uncover Evidence in Two Mouse Models That Metastases to the Lung Mostly Derive from Disseminating Epithelial Cells, but Not From Cells that Have Undergone the Epithelial-to-mesenchymal Transition (EMT). Further, they Found That Cells Which had Undergone EMT Became more Resistant to Therapeutic Drugs.The report appears in Nature.
- Using Several Mouse Models to Elucidate Various Stages of the Process, Researchers Demonstrate That Patrolling Monocytes Positive for Nr4a1 Prevent Cancer Metastasis to Lung.
- Using Cell Lines, Human Tissue Specimens, and a Nude Xenograft Mouse Model, Researchers Demonstrate That Merlin, the Protein Encoded by NF2, Suppresses the Growth and Metastasis of Pancreatic Ductal Adenocarcinoma In Vitro and In Vivo.
- Researchers Develop a Chimeric Orthotopic Mouse Model to Elucidate the Contribution of Bone-marrow -derived Myeloid Cells to Glioblastoma Progression Through Inducing Resistance to Anti-Angiogenic Therapies Via Cytokine Signaling.
- Researchers Develop an Orthotopic Mouse Xenograft Model of Atypical Teratoid Rhabdoid Tumor to Demonstrate the Ability of the Oncolytic Measles Virus to Destroy Cancer Cells.
- Researchers Demonstrate That the Antioxidant N-acetylcysteine (NAC) Increases the Number of Lymph Node Metastases in an Endogenous Mouse Model of Malignant Melanoma and That NAC and Vitamin E Both Increase the Migratory and Invasive Properties of Human Malignant Melanoma Cells In Vitro.