New Method for Culturing Tumor Cells in a 3D Matrix Before Injecting the
Cells into Mice Elicits Antibody Responses That May Identify New
Reported in the September issue of PNAS, the method led to the identification of 4C3, a mouse antibody that can reduce the rate of proliferation of breast cancer cells.
- Researchers at the University of Michigan Medical School Show that Rapamycin Can Enhance the Effectiveness of Immunotherapy in a Mouse Model of Glioma.
- Researchers at The Broad Institute and MIT Develop a Cas9 Mouse to Facilitate In Vivo Gene Editing and Model Lung Adenocarcinoma.
Have Used a Synthetic Form of Vitamin D to Destroy Pancreatic Cancer
Cells in a Mouse Model.
When combined with gemcitabine, the approach reduced tumor volume and increased survival by 57%.
- Indocyanine Green, a Fluorescent Dye That Preferentially Accumulates in Cancerous Tissue Improves Surgical Outcomes in Dogs and Humans.
- Research at the University of Kansas Report That a Mouse Strain With the Genetic Modifier Pla2g2a Develop Fewer Tumors Arising From Mutant Forms of the Adenomatous Polyposis Coli Protein.
- Surgeons at Memorial Sloan Kettering Have Found That Using a Handheld Scanner to Detect Nanoprobes Deposited into Brain Tumors Allows More Accurate Resection, Reducing the Rate of Recurrence in a Mouse Model.
- Scientists Have Sequenced the Genome of the Naked Mole Rat, an Accomplishment That Will Aid Research Into the Species’ Resistance to Cancer.
With Rats, Researchers Have Invented a Microscopic Pump to Deliver
Anticancer Drugs Into Tumors.
The work is reported in the August 17 issue of Nature Medicine.
- Using C. elegans, Researchers Find That
Invasive Cells Use Moving Receptors to Seek Out Netrin, a Protein Known
to be Implicated in Metastasis.
The study was published in the August 25 issue of the Journal of Cell Biology.
- Investigating the Role
of the Vagus Nerve in a Mouse Model of Stomach Cancer, Researchers Have
Found that Severing the Nerve or Using Botox to Suppress its Function Can
Slow Disease Progression, Make Tumors More Responsive to Chemotherapy,
and Prolong survival.
The mechanism appears to be M3-receptor-mediated Wnt signaling.
- Using a Mouse Model of Human Non-alcoholic Steatohepatitis, Researchers Have Found That Suppressing Tumor Necrosis Factor Can Reduce the Incidence of Liver Cirrhosis and Slow Progression to Hepatocellular Carcinoma.
Demonstrate That a Commercially Available Compound Composed of Metabolites
Produced by S. aureus Can
Induce Tumor Necrosis While Activating T Cells in a Mouse Model of
The S. aureus bioproduct used includes enterotoxin C, proteins, and 18 amino acids.
- Researchers at the
Koch Institute for Integrative Cancer Research at MIT Have Reported That They Have Used Nanoparticles to
Deliver miR-34a Combined With an
siRNA in a Mouse Model of Lung Cancer.
MiR-34a downregulates Kras gene expression and led to tumor regression in the model.
- Researchers Use Iron Nanoparticles to Destroy Tumors Through the Induction of Magnetic Hyperthermia in Animal Models.
- Johns Hopkins Scientists Use the Soil Bacterium Clostridium novyi to Treat Hypoxic Solid Tumors in Dogs and a Human With Leiomyosarcoma.
- Scientists at the
University of Auckland Used Screening With Zebrafish Embryos to Identify
Four Potential Anticancer Drug
Candidates Intended to Retard Metastasis Through the Lymphatic System.
The drug candidates—kaempferol, leflunomide, cinnarizine, and flunarizine were also tested in mouse models.
- A New Therapy for Glioblastoma That Combines Two Types of Immunotherapy [CTLA-4 and 4-1BB (CD137)] With Highly Focused Radiation Therapy Shows Promise in a Mouse Model.
- Researchers at MIT
Have Shown That CRISPR/Cas Gene-Editing Technology Can Generate Mouse
Models of Specific Cancers More Easily and Cheaply Than Traditional
The scientists used CRISPR to directly mutate the tumor suppressor genes p53 and Pten, inducing liver cancer in mice.
- Veterinary Researchers Use Gold NanoParticles Combined With Targeted Laser Treatment in Dogs and Cats With Solid Tumors.
- A Study in Mice and Rats Demonstrates That Malignant Glioma Cells Secrete Galectin-1 to Evade Immune-System Surveillance by Natural Killer Cells During Early Tumor Formation.
- Stanford Researchers Develop a Novel Decoy Protein That Disrupts Metastasis in Mice With Aggressive Breast or Ovarian Cancers.
Find That a Strain of Mice That Lack Syndecan-1and Therefore Do Not
Develop an Intradermal Fat Layer Exhibit Higher Resistance to Tumor
The mechanism is thought to be stress checkpoint p38a activation.
- Researchers Have Found Similarities Between Portions of the Epigenomes of Dogs and Humans That Are Implicated in the Epithelial-toMesenchymal Transition Leading to Cancer Progression.
- Testosterone Shown to Raise the Risk of Prostate Cancer and Exacerbate Effects of Carcinogenic Chemical Exposure in Rats.
Model of Colon Cancer in D.
Melanogaster Has Been Developed and Used to Identify a Human Gene
That Promotes Cell Proliferation in Early Colon Cancer.
The gene is identified as Mirror in drosophila and IRX in human.
- Researchers Have Used Aplysia, a Sea Snail, as a Model to Explore Mechanisms Leading to Cognitive Loss Following Chemotherapy.
- Using a Mouse Model of Breast Cancer, Researchers Have Discovered That Erbin, the Protein Partner of the Oncogene ErbB2/HER2, Which is Highly Expressed in About 25% of Breast Cancers, Contributes to Disease Progression. The study appears in PNAS.
- Researchers at UCSF Identify a Previously Unknown Type of Immune Cell in Mice— Antigen-presenting CD103+ Dendritic Cells—That Is Associated With Less-Severe Cancer Outcomes.
- Using a Mouse Model of Melanoma, UK Scientists Demonstrate That Lysophosphatidic Acid Induces Chemotaxis and May Provide a Target to Prevent Metastasis.
NYU Study in Mice Demonstrates That Blocking the Enzyme JMJD3 Can Suppress
the Progression of T-cell Acute Lymphoblastic Leukemia.
The study appears in Nature.
- A Study Has
Shown That a Compound That Inhibits the TOPK Protein Can Eradicate Tumor
Cells in a Mouse Xenograft Model of Aggressive Human Lung Cancer.
The study appears in Science.
- Researchers Show that Exosomes Containing miRNA Produced by Breast-cancer Cells Can Alter Gene Expression in Normal Cells, Leading to Tumor Formation When the Contaminated Cells Are Injected Into Mice.
Inhibitors Shown to Effective Against Ewing Sarcoma in Mice When Given in
Combination With Irinotecan and Temozolomide.
The triple therapy is now in clinical trials led by researchers at St. Jude.
- Researchers at Harvard Have Developed Stem Cells That Produce Pseudomonas Exotoxin to Kill Glioblastoma Cells in a Mouse Model.