- Researchers at Fred Hutchinson Have Demonstrated That Treating a KPC Mouse Model of Pancreatic Ductal Carcinoma With T Cells Engineered to Express Affinity-enhanced T Cell Receptors Reactive to Mesothelin Can Nearly Double Survival Rates, With or Without Concomitant Radiation Therapy or Chemotherapy. They hope to carry out an early-phase clinical trial within the next year.
- An International Team of Scientists Has Developed a Method for Using CRISPER/Cas-9 Multiplex Mutagenesis to Engineer Mouse Models , Allowing for High-throughput Analysis of Gene Function. They exemplified the approach in a model of hepatocellular carcinoma. The study appears in PNAS.
- An Analysis of C. elegans Development Yields Insights into the Basic Biology of Metastasis: Dividing Cells Cannot Act Invasively When Proliferating. The transcription Factor NHR67/TLX and the histone deactylase HDA-1 are the crucial regulators of cellular invasiveness, causing G1cell-cycle arrest.
- Researchers at the Spanish National Cancer Research Center Have Developed a Mouse Model of Diamond-Blackfan Anemia That Reveals a Molecular Mechanism—the Mutated Ribosomal Protein Rpl11—Common to the Blood Disorder and Radiation-induced Lymphomagenesis.
- A Tricyclic Antidepressant Combined With an Anticoagulant Can Increase the Rate of Tumor-cell Autophagy in a Mouse Model of Glioma.
- UK Researchers Demonstrate that a Focal Adhesion Kinase Inhibitor Already in Clinical Trials Can Stimulate the Immune System to Destroy Squamous Cell Carcinoma in a Mouse Model.
- A Diet Containing Dried Plums Reduces the Risk of Colon Cancer in a Rat Model by Promoting the Retention of Beneficial Bacteria in the Gut.
- o Researchers Track the Movement of Individual Metastatic Breast Cancer Cells in a Patient-derived Xenograft (PDX) Mouse Model. Using a fluorescence-activated cell sorting (FACS)-based assay, the research team delineated a “hierarchy” of metastatic cell types and found that a subset characterized by stem-cell-like properties has a higher capacity to initiate new tumors than do metastatic cells lacking such markers. The study appears in Nature.
- Stanford Scientists Demonstrate That a Combination of an Inhibitor of BET proteins and a Histone Deacetylase Inhibitor Induces Tumor Regression in a CRISPR-Cas 9 Modified Mouse Model of Pancreatic Ductal Adenocarcinoma. The report appears in Nature Medicine.
- Using a Mouse Model With a Cachectic Phenotype, Researchers Have Identified a Molecular Mechanism—Fn14, a Tumor Necrosis Factor Receptor and Its Ligand—That Contributes to the Disorder. Cachexia, a metabolic disease that leads to muscle wasting, weight loss, and other symptoms, affects 50% to 80% of patients with solid tumors and may account for approximately 25% of cancer deaths.
- Researchers Have Developed a Compound That Inhibits the Stat3 Protein, Reducing the Risk of Relapse in a Mouse Model of Acute Myeloid Leukemia.
- Researchers Have Implanted Biomaterial Scaffolds That Can Capture Circulating Metastatic Cells in an Orthotopic Mouse Model of Human Breast Cancer Metastasis.
- COX Inhibitors Combined With Immunotherapy Can Induce Tumor Regression in a Mouse Model of Cutaneous Melanoma Characterized by Mutated Braf Through Inhibiting the Production of Prostaglandin E2.
- Researchers Demonstrate That the Use of 5-azacytidine, a Demethylating Agent, Can Reactivate a Viral Defense Pathway, Leading to an Enhanced Anti-tumor Response in a Mouse Model of Melanoma.
- MIT Researchers Have Developed a Nanosensor Composed of a Single-walled Carbon Nanotube Attached to a Polymer That Can Detect Nitric Oxide, a Marker of Inflammation Frequently Associated with Certain Types of Cancer in Mice. The detector remained active for more than 400 days with no adverse effects. The article appears in Nature Nanotechnology.
- A Mouse Study Suggests That Obesity Increases the Risk of Mammary Cancer by Inducing Fibrosis in the Extracellular Matrix.
- A Miniature Chemical Sensor With a Wireless Readout Implanted During Biopsy Can Measure Metabolic Markers Associated With Tumor Response to Treatment in a Mouse Xenograft Model.
- In a Mouse Model of Colorectal Carcinogenesis, Researcher s Found that a Lower Dose of Resveratrol Is More Effective Than a Dose 200 Times Higher.
- Researchers at the University of Illinois Have Developed a New Transgenic Porcine Model of Cancer. The model is based on the Cre recombinase inducible transgenes KRASG12D and TP53R167H.
- Deletion of the Amino Acid Transporter Gene Slc6a14 Retards Tumor Progression in a Mouse Model of Breast Cancer.
- Irregular Sleep Patterns, or Circadian Disturbance, Are Shown to be Causally Related to Cancer Progression in p53R270H©/+ WAP Cre Conditional Mutant Mice Prone to Develop Breast Cancer.
- Baseline Tumor Growth Is Accelerated and Immune Control Is Decreased in Laboratory Mice Housed in Atypically Cold Environments. The study appears in PNAS.
- Restoration of the Adenomatous Polyposis Coli (APC) Tumor-repressor Induces Tumor Regression in a Mouse Model of Human Colorectal Cancer.