- Veterinary Researchers Are Studying the Use of Oncolytic Virus Therapy Combined With Surgery in Cats With Breast Cancer.
- Modulation of Murine Breast Tumor Vascularity, Hypoxia and Chemotherapeutic Response by Exercise.
- Annotated Features of Domestic Cat—Felis catus Genome.
- In a Phase III Trial, Researchers are Evaluating the Efficacy of the Orally Delivered Drug Kinavet-CA1 in Treating Mast Cell Tumors in Dogs.
- Therapy-induced Tumour Secretomes Promote Both Resistance and Tumour Progression. In Nature, researchers report that therapy with BRAF, ALK, or EGFR kinase inhibitors can induce drug resistance in human melanoma or lung-adenocarcinoma cells. When these resistant cells were transplanted into mice, however, they began secreting signals that could either promote disease progression or increase the cells’ susceptibility to combination therapy by inhibiting RAF and PI(3)K/AKT/mTOR intracellular signaling.
- Veterinary Researchers Use Gold Nanoparticles in Combination with Laser Therapy to Treat Solid Tumors in Dogs and Cats in a Clinical Trial.
- Increasing the Efficiency of Precise Genome Editing With CRISPR-Cas9 by Inhibition of Nonhomologous End Joining. The researchers tested this technique in mammalian cell lines and mouse zygotes using the DNA ligase inhibitor Scr7 (a known anti-cancer agent) to inhibit nonhomologous end joining in favor of a second, more precise repair mechanism: homology-directed repair.
- Reprogramming of Primary Human Philadelphia Chromosome-positive B Cell Acute Lymphoblastic Leukemia Cells into Nonleukemic Macrophages.
- Breaking the Depth Dependency of Phototherapy With Cerenkov Radiation and Low Radiance Responsive Nanophotosensitizers. In Nature Nanotechnology, researchers report using a mouse model with aggressive HT1080 tumors to demonstrate the efficacy of using fluorodeoxyglucose positron-emission tomography (FDG-PET) in combination with nanoparticles containing titanium dioxide, a photosynthesizer and a source of free radicals, as well as titanocene to induce apoptosis in cancer cells.
- Modeling Colorectal Cancer Using CRISPR-Cas9–mediated Engineering of Human Intestinal Organoids.
- New Mouse Models Mimic Biology of Human Cancer. Two models are described: a diversity-outbred mouse showing varying responses to benzene, which can be used to help define exposure limits for humans; patient-derived xenograft models, many of which are now being used in clinical trials at M.D. Anderson.
- Predicting Clinical Response to Anticancer Drugs Using an Ex Vivo Platform That Captures Tumour Heterogeneity. Researchers have engineered personalized tumor “ecosystems” using explants into mice together with a machine-learning algorithm termed CANScript to predict clinical responses to select anticancer drugs.
- Detecting Cancers Through Tumor-activatable Minicircles That Lead to a Detectable Blood Biomarker. Researchers established the specificity and sensitivity of a class of nonviral vectors termed tumor-activatible minicircles by assessing the system’s ability to differentiate mice bearing human metastatic melanoma lesions from cancer-free mice.
- Mouse Low-grade Gliomas Contain Cancer Stem Cells With Unique Molecular and Functional Properties.
- Unraveling Heterogeneous Susceptibility and the Evolution of Breast Cancer Using a Systems Biology Approach. For this study, the researchers generated a cohort of MMTV-ErbB2 transgenic mice from FVB, F1FVBxC57 and backcross (F1BX) genetic backgrounds.
- Immunological Mechanisms of the Antitumor Effects of Supplemental Oxygenation.
- Tumourigenic Canine Osteosarcoma Cell Lines Associated with Frizzled-6 Up-regulation and Enhanced Side Population Cell Frequency.
- Injectable, Spontaneously Assembling, Inorganic Scaffolds Modulate Immune Cells In Vivo and Increase Vaccine Efficacy.
- Monoamine Oxidase A Inhibitor–near-infrared Dye Conjugate Reduces Prostate Tumor Growth.
- Interrogating the Function of Metazoan Histones Using Engineered Gene Clusters. UNC researchers have developed a platform using Drosophila to generate and analyze histone genotypes.
- A U Penn Veterinary Team Has Identified MS12, an RNA Binding Protein, as a Possible Therapeutic Target for Colon Cancer. The researchers bred mice in which they could induce MS12 overexpression and study its role in carcinogenesis.
- Polymeric Nanoparticles for Nonviral Gene Therapy Extend Brain Tumor Survival In Vivo.
- Local Iontophoretic Administration of Cytotoxic Therapies to Solid Tumors. The researchers tested an implanted drug-delivery device that uses electric fields to infuse drugs into tissue in three orthotopic mouse models of cancer, including pancreatic and breast, and in a canine model.
- INK4 Locus of the Tumor-resistant Rodent, the Naked Mole Rat, Expresses a Functional p15/p16 Hybrid Isoform. Scientists have discovered a fourth tumor-suppressor protein isoform they have termed pALT(INK4a/b) encoded in the INK4 locus of naked mole rats that may help to account for the high degree of tumor resistance in the species. In contrast to the mole rat, the INK4 locus encodes only three distinct tumor-suppressor proteins in human and mouse. The study appears in PNAS.
- Visualization of Fluid Drainage Pathways in Lymphatic Vessels and Lymph Nodes Using a Mouse Model to Test a Lymphatic Drug Delivery System.
- Comparison of the Transcriptional Landscapes Between Human and Mouse Tissues.
- Radiation Protection of the Gastrointestinal Tract and Growth Inhibition of Prostate Cancer Xenografts by a Single Compound. Researchers demonstrate the effects of RTA 408, a CDDO triterpenoid, in providing radiation protection and slowing the proliferation of human prostate cancer cells in a mouse xenograft model.
- A High-fat Diet Containing Whole Walnuts (Juglans regia) Reduces Tumour Size and Growth Along With Plasma Insulin-like Growth Factor 1 in the Transgenic Adenocarcinoma of the Mouse Prostate Model.
- Elevated Cell Invasion in a Tumor Sphere Culture of RSV-M Mouse Glioma Cells.
- High-resolution Genome-wide DNA Methylation Maps of Mouse Primary Female Dermal Fibroblasts and Keratinocytes.
- Preclinical Screening for Acute Toxicity of Therapeutic Monoclonal Antibodies in a Hu-SCID Model.
- Assessment of Patient-derived Tumour Xenografts (PDXs) as a Discovery Tool for Cancer Epigenomics.
- Organoid Models of Human and Mouse Ductal Pancreatic Cancer.
- HET0016, a Selective Inhibitor of 20-HETE Synthesis, Decreases Pro-angiogenic Factors and Inhibits Growth of Triple Negative Breast Cancer in Mice.
- Co-treatment With Therapeutic Neural Stem Cells Expressing Carboxyl Esterase and CPT-11 Inhibit [sic]Growth of Primary and Metastatic Lung Cancers in Mice.
- Sequencing the Mouse Y Chromosome Reveals Convergent Gene Acquisition and Amplification on Both Sex Chromosomes.