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International Mouse Phenotyping Consortium (IMPC)

The International Mouse Phenotyping Consortium (IMPC) comprises a group of major mouse genetics research institutions along with national funding organisations formed to address the challenge of developing an encyclopedia of mammalian gene function.

The International Mouse Phenotyping Consortium (IMPC) comprises a group of major mouse genetics research institutions along with national funding organisations formed to address the challenge of developing an encyclopedia of mammalian gene function.

The IMPC envisages a ten year programme to undertake a broad-based, systematic genome-wide phenotyping project of knockout mice generated from the embryonic stem cell mutant resources developed by the International Knock-out Mouse Consortium (IKMC). Each mutant line will undergo a broad suite of high-throughput tests to identify developmental, anatomical, physiological, behavioural and pathological phenotypes.

It is anticipated that this landmark programme will produce a paradigm shift in our understanding of basic molecular, cellular and systems biology, as well as feed the biopharmaceutical pipeline by enhancing our understanding of the genetic bases for disease.

Importantly, this internationally co-ordinated programme will build upon the major mouse genetics programmes and infrastructures around the world enabling access to high quality, freely accessible phenotype data covering all major organ systems, as well as access to mouse knockout strains of lasting biological and medical value.

An IMPC Steering Committee (SC) was formed to develop an operational plan and harness the major world-wide mouse research programmes and infrastructures in a strategic and coordinated effort.

The IMPC is currently composed of 10 research institutions and national funders from six countries and is expected to increase membership as the programme moves forward. The Committee's goal was to develop a plan to harness the major world-wide mouse research programmes and infrastructures in a strategic and coordinated effort to undertake a broad-based, systematic genome-wide phenotyping project of knockout mice in order to provide the wider research community with a long lasting resource of mammalian gene function information.

  • MRC Harwell (Steve Brown, current Chair, Tom Weaver)
  • MRC (Nathan Richardson, Paula Clements)
  • NIH (Jane Peterson, Eric Green, Jim Battey, Colin Fletcher, Mark Guyer)
  • Sanger Institute (Alan Bradley, Karen Kennedy)
  • Wellcome Trust (Michael Dunn, Clare McVicker)
  • Infrafrontier (Martin Hrabe de Angelis)
  • Helmholtz Zentrum Munich (GMC) (Martin Hrabe de Angelis)
  • Toronto Centre for Phenogenomics (TCP) (Colin McKerlie)
  • Institut Clinique de la Souris (ICS) (Yann Herault)
  • Australian Phenomics Network (AP) (Adrienne McKenzie)
  • RIKEN BioResource Center (JMC) (Yuichi Obata)
  • CNR Monterotondo (IMC) (Tocchini Glauco)
  • Genome Canada (Cindy Bell)
  • MARC, Nanjing (Xiang Gao)
  • European Commission (Patrik Kolar, observer)
  • Secretariat (Mark Moore, Jörg Roßbacher)



For more information see the IMPC website at http://www.mousephenotype.org/