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Mouse Collaborative Cross Articles in Genetics Society of America Journals

The Genetics Society of America (GSA) is pleased to announce the February 2012 publication of a series of 15 articles across its journals,GENETICS and G3: Genes|Genomes|Genetics, on the mouse “Collaborative Cross” (CC) resource and its companion mouse resource, the “Diversity Outbred” (DO).

The CC mice have 90 percent of the genetic diversity present in laboratory mice, mirroring the genetic diversity in humans.  Dr. Gary Churchill (The Jackson Laboratory) and one of the leaders of the CC project explained that “initial screening with this genetically diverse and heterogeneous model may allow for more realistic assessments of the risk of adverse effects and may be a reliable route for applying findings from mouse to human populations.”

This resource, developed by an international consortium, was also led by Drs. David Threadgill (North Carolina State University and University of North Carolina Lineberger Comprehensive Cancer Center), who originally proposed the idea of the CC, and Dr. Fernando Pardo-Manuel de Villena (UNC Chapel Hill Department of Genetics and Lineberger).  The mice are ‘curated’ at UNC-Chapel Hill.

The issues of both journals will be online on February 16, 2012.  GENETICS can be accessed at and G3 is available at  The journals are published by GSA, which conducts activities on behalf of the entire genetics community, including scientific meetings for several model organism communities, developing and disseminating educational resources, and advocating for policies to support and promote scientific research and education. For more information about GSA, see