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Role of Environmental Chemical Exposures in the Development of Obesity, Type 2 Diabetes and Metabolic Syndrome (R01)

PA-12-185

The Funding Opportunity Announcement, issued by the National Institute of Environmental Health Sciences (NIEHS), encourages grant applications to understand the role of environmental chemical exposures in the development of obesity, type 2 diabetes and/or metabolic syndrome. Applications must link an environmental exposure to the increased incidence of weight gain, glucose tolerance/insulin sensitivity and aspects of metabolic syndrome in animal models or human studies. While any exposure window is acceptable it is anticipated that the most sensitive time for exposures to affect the disease outcomes will be during development e.g. in utero and/or neonatal or early childhood. For human studies developmental exposures (in utero and early childhood) should be linked to early biomarkers of disease onset. Animal studies should focus on identifying environmental chemicals that alter endpoints indicative of affecting disease development and the site and mechanism(s) of the effects that lead to the increased disease incidence.

http://grants.nih.gov/grants/guide/pa-files/PA-12-185.html