Spindle-cell squamous carcinoma

Spindle cell squamous carcinoma is frequently a diagnostic challenge. Evidence supporting this diagnosis include: focal keratinization or immunoperoxidase staining for cytokeratin, evidence of origin from adjacent squamous cell carcinoma or overlying squamous cell carcinoma in situ, or ultrastructural evidence (desmosome formation). Spindle cell tumors that arise in UV irradiated or mice treated with topical chemical carcinogens that resemble so-called "fibrosarcoma" are very frequently spindle cell squamous carcinoma.


Spindle-cell squamous carcinoma Click image to magnify
Image Courtesy of Dr. Marcus Bosenberg