Slide 017

Slide ID:

017

Collection of murine pulmonary tumors - Slide 017

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Submitting Investigator:

Alvin M. Malkinson

Mouse Age:

14 months

Mouse Sex:

female

Mouse Strain:

C57B6

Genotype:

wild type

Genetic Modification Details:

none

Other Factors:

vinyl carbamate

Gross Morphology:

none

Method of Fixation:

10 % formalin

Annotations:

Acinar adenocarcinoma.

In one section there is a large mass, replacing most of the lung lobule, composed of undulating tubular irregular arrays lined by cuboidal regularly spaced cells. The lumens of these tubular arrays are distended and contain necrotic cell debris mixed with mucin and eosinophilic acellular material. The neoplastic cells have moderate amounts of cytoplasm with occasional bright eosinophilic granules or variably sized pale basophilic vacuoles (mucin). The nuclei are round to oval and basal with occasional prominent nucleoli and moderate degree of anisokaryosis.
In a small area peripheral to the neoplasm, there are variable numbers of acidophilic and foamy macrophages.

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