Slide 071

Slide ID:

071

Collection of murine pulmonary tumors - Slide 071

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Submitting Investigator:

Sabine Rehm

Mouse Age:

NA

Mouse Sex:

NA

Mouse Strain:

B6C3F1

Genotype:

NA

Genetic Modification Details:

none

Other Factors:

3-methylcholanthrene (MCA); induced intratracheally

Gross Morphology:

none

Method of Fixation:

Formalin

Annotations:

Adenosquamous carcinoma.
There are multiple ill defined areas of neoplastic cells and in some areas there is a continuum from tubular papillary undulating arrays lined by single cuboidal epithelium to solid nests of stratified epithelium to lobules with layered keratinized formation some of which have variable amounts of keratin debris. The neoplastic cells are round to cuboidal with moderate amount of eosinophilic cytoplasm with indistinct borders. The nucleus is oval with stippled to vesicular chromatin and prominent small nuclei. Mitotic figures can be seen scattered through out the neoplasia. In some adjacent areas of normal parenchyma there are moderate numbers of foamy macrophages.

References:

Rehm, S., and Kelloff, G. J. (1991). Histologic characterization of mouse bronchiolar cell hyperplasia, metaplasia, and neoplasia induced intratracheally by 3-methylcholanthrene. Exp. Lung. Res. 17, 229-244.