Slide 070

Slide ID:

070

Collection of murine pulmonary tumors - Slide 070

Click image to enlarge
Submitting Investigator:

Sabine Rehm

Mouse Age:

NA

Mouse Sex:

NA

Mouse Strain:

Swiss mice

Genotype:

NA

Genetic Modification Details:

none

Other Factors:

N-nitroso-tris-chloroethylurea, induced cutaneously (skin painting)

Gross Morphology:

none

Method of Fixation:

Formalin

Annotations:

Squamous cell carcinoma.
There are multiple ill-defined areas of neoplastic cells that blend into the adjacent parenchyma and efface the normal pulmonary architecture. The neoplastic cell population ranges from solid closely arranged nests lined by single cuboidal epithelium to large lobules lined by stratified keratinized epithelium with variably sized dilated lumens containing layered parakeratotic epitheliumor aggregates of sloughed neoplastic epithelium. The neoplastic cells are medium to large size with moderate amounts of eosinophilic cytoplasm with indistinct borders, oval to round shape nuclei with stippled chromatin and prominent nuclear membrane and nucleoli. Occasional individual cell keratinization can be seen. A moderate degree of anisokaryosis and megalocytosis are present. The adjacent parenchyma has moderate number of foamy macrophages.

References:

Rehm, S., Lijinsky, W., Singh, G., and Katyal, S. L. (1991b). Mouse bronchiolar cell carcinogenesis. Histologic characterization and expression of Clara cell antigen in lesions induced by N-nitrosobis-(2-chloroethyl) ureas. Am. J. Pathol. 139, 413-422.