Proliferative Lesions of the Lung
This WEB site contains a digital atlas of virtual histological slides with representative mouse and human pulmonary proliferative lesions. It complements the paper "Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancers Consortium" by Alexander Yu. Nikitin, Ana Alcaraz, Miriam R. Anver, Roderick T. Bronson, Robert D. Cardiff, Darlene Dixon, Armando E. Fraire, Edward W. Gabrielson, William T. Gunning, Diana C. Haines, Matthew H. Kaufman, R. Ilona Linnoila, Robert R. Maronpot, Alan S. Rabson, Robert L. Reddick, Sabine Rehm, Nora Rozengurt, Hildegard M. Schuller, Elena N. Shmidt, William D. Travis, Jerrold M. Ward and Tyler Jacks published in Cancer Research 64: 2307-2316, 2004
Please note that slides frequently have more than one lesion. For didactic purposes, the annotations do not always describe all lesions. All images have been scanned with the ScanScope (Aperio Technologies) equipped with objective 20X. The resulting magnification is about 320 folds. Excessive zooming (in most cases over 3 "zoom in" clicks) will result in magnification exceeding that of the original scan and image will appear out of focus.
This work was supported by the Mouse Models of Human Cancers Consortium (MMHCC) Pathology Standing Committee funding (CA84241 and CA84242 to A. Yu. Nikitin) and with Federal funds from the National Cancer Institute, NIH, under contract N01-C0-124000. A. Yu. Nikitin is a recipient of the NCRR, NIH Midcareer Award in Mouse Pathobiology (RR017595).