Antibody Glossary

The components of the immune system have diverse roles in the initial development of cancers, progression of early-stage malignancies to invasive tumors, establishment of metastatic lesions, tumor dormancy, and response or resistance to therapy.  Characterizing the components of the immune system and their functional status in tissues and in tumors requires the use of highly specific reagents.  Researchers employ antibodies in a variety of in vitro and in vivo applications to delineate, enrich, or deplete specific immune subsets in order to understand their role(s) in tumorigenesis.   This is a glossary of validated reagents and protocols that are useful for functional phenotyping of the immune system in murine cancer models.